USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P13716 USC-OGP 2-DE database:  P13716 P13716 General information about the entry View entry in simple text format Entry name HEM2_HUMAN Primary accession number P13716 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Delta-aminolevulinic acid dehydratase; Short=ALADH; EC=4.2.1.24; AltName: Full=Porphobilinogen synthase;. Gene name Name=ALAD Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0446: pI=6.16; Mw=36830 Cross-references UniProtKB/Swiss-Prot P13716; HEM2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name HEM2_HUMAN Primary accession number P13716 Secondary accession number(s) A8K375 B2R6F2 Q16870 Q16871 Q9BVQ9 Sequence was last modified on  January 1, 1990 (version 1) Annotations were last modified on  March 15, 2017 (version 190) Name and origin of the protein Description RecName: Full=Delta-aminolevulinic acid dehydratase; Short=ALADH; EC=4.2.1.24; AltName: Full=Porphobilinogen synthase; Gene name Name=ALAD Encoded on Name=ALAD Keywords 3D-structure; Allosteric enzyme; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Heme biosynthesis; Lyase; Metal-binding; Phosphoprotein; Polymorphism; Porphyrin biosynthesis; Reference proteome; Zinc. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M13928; AAA51687.1; -; mRNA EMBL X64467; CAA45796.1; -; Genomic_DNA EMBL S99468; AAC60581.1; -; mRNA EMBL S99471; AAC60582.1; -; mRNA EMBL AK290490; BAF83179.1; -; mRNA EMBL AK312552; BAG35449.1; -; mRNA EMBL AY319481; AAP72012.1; -; Genomic_DNA EMBL AL137066; CAH70099.3; -; Genomic_DNA EMBL BC000977; AAH00977.3; ALT_INIT; mRNA CCDS CCDS6794.2; -. [P13716-1]; . PIR A26478; A26478; . RefSeq NP_000022.3; NM_000031.5. [P13716-1]; . RefSeq NP_001003945.1; NM_001003945.2. [P13716-2]; . RefSeq XP_011516666.1; XM_011518364.2; . UniGene Hs.1227; -; . PDB 1E51; X-ray; 2.83 A; A/B=1-330 PDB 1PV8; X-ray; 2.20 A; A/B=1-330 PDB 5HMS; X-ray; 2.80 A; A/B=1-330 PDB 5HNR; X-ray; 2.83 A; A/B=1-330 PDBsum 1E51; -; . PDBsum 1PV8; -; . PDBsum 5HMS; -; . PDBsum 5HNR; -; . ProteinModelPortal P13716; -; . SMR P13716; -; . BioGrid 106712; 22; . IntAct P13716; 1; . STRING 9606.ENSP00000386284; -; . BindingDB P13716; -; . ChEMBL CHEMBL3126; -; . DrugBank DB02878; 3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid; . DrugBank DB02260; 4-Oxosebacic Acid; . DrugBank DB04781; 5-hydroxyvaleric acid; . DrugBank DB00855; Aminolevulinic acid; . DrugBank DB02068; Delta-Amino Valeric Acid; . DrugBank DB02239; Laevulinic Acid; . DrugBank DB02272; Porphobilinogen; . iPTMnet P13716; -; . PhosphoSitePlus P13716; -; . SwissPalm P13716; -; . BioMuta ALAD; -; . DMDM 122833; -; . OGP P13716; -; . REPRODUCTION-2DPAGE P13716; -; . SWISS-2DPAGE P13716; -; . EPD P13716; -; . MaxQB P13716; -; . PaxDb P13716; -; . PeptideAtlas P13716; -; . PRIDE P13716; -; . Ensembl ENST00000409155; ENSP00000386284; ENSG00000148218. [P13716-1]; . GeneID 210; -; . KEGG hsa:210; -; . UCSC uc011lxf.3; human. [P13716-1]; . CTD 210; -; . DisGeNET 210; -; . GeneCards ALAD; -; . HGNC HGNC:395; ALAD; . HPA HPA021023; -; . HPA HPA022124; -; . MalaCards ALAD; -; . MIM 125270; gene; . MIM 612740; phenotype; . neXtProt NX_P13716; -; . OpenTargets ENSG00000148218; -; . Orphanet 100924; Porphyria due to ALA dehydratase deficiency; . PharmGKB PA24687; -; . eggNOG KOG2794; Eukaryota; . eggNOG COG0113; LUCA; . GeneTree ENSGT00390000006998; -; . HOGENOM HOG000020323; -; . HOVERGEN HBG001222; -; . InParanoid P13716; -; . KO K01698; -; . OMA MHHATLR; -; . OrthoDB EOG091G0FMX; -; . PhylomeDB P13716; -; . TreeFam TF300665; -; . BioCyc MetaCyc:HS07501-MONOMER; -; . BRENDA 4.2.1.24; 2681; . Reactome R-HSA-189451; Heme biosynthesis; . Reactome R-HSA-6798695; Neutrophil degranulation; . UniPathway UPA00251; UER00318; . ChiTaRS ALAD; human; . EvolutionaryTrace P13716; -; . GeneWiki ALAD; -; . GenomeRNAi 210; -; . PRO PR:P13716; -; . Proteomes UP000005640; Chromosome 9; . Bgee ENSG00000148218; -; . CleanEx HS_ALAD; -; . ExpressionAtlas P13716; baseline and differential; . Genevisible P13716; HS; . GO GO:0005829; C:cytosol; IBA:GO_Central; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IEA:Ensembl; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0003824; F:catalytic activity; TAS:ProtInc; . GO GO:0042802; F:identical protein binding; IPI:UniProtKB; . GO GO:0032791; F:lead ion binding; IDA:UniProtKB; . GO GO:0004655; F:porphobilinogen synthase activity; IDA:UniProtKB; . GO GO:0008270; F:zinc ion binding; IDA:UniProtKB; . GO GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl; . GO GO:0071284; P:cellular response to lead ion; IEA:Ensembl; . GO GO:0006783; P:heme biosynthetic process; IDA:UniProtKB; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0051260; P:protein homooligomerization; IPI:UniProtKB; . GO GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway; . GO GO:0014823; P:response to activity; IEA:Ensembl; . GO GO:0010044; P:response to aluminum ion; IEA:Ensembl; . GO GO:0043200; P:response to amino acid; IEA:Ensembl; . GO GO:0046685; P:response to arsenic-containing substance; IEA:Ensembl; . GO GO:0046686; P:response to cadmium ion; IEA:Ensembl; . GO GO:0032025; P:response to cobalt ion; IEA:Ensembl; . GO GO:0042493; P:response to drug; IEA:Ensembl; . GO GO:0045471; P:response to ethanol; IEA:Ensembl; . GO GO:0070542; P:response to fatty acid; IEA:Ensembl; . GO GO:0051384; P:response to glucocorticoid; IEA:Ensembl; . GO GO:0009635; P:response to herbicide; IEA:Ensembl; . GO GO:0001666; P:response to hypoxia; IEA:Ensembl; . GO GO:0010212; P:response to ionizing radiation; IEA:Ensembl; . GO GO:0010039; P:response to iron ion; IEA:Ensembl; . GO GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl; . GO GO:0046689; P:response to mercury ion; IEA:Ensembl; . GO GO:0051597; P:response to methylmercury; IEA:Ensembl; . GO GO:0006979; P:response to oxidative stress; IEA:Ensembl; . GO GO:0070541; P:response to platinum ion; IEA:Ensembl; . GO GO:0010269; P:response to selenium ion; IEA:Ensembl; . GO GO:0010266; P:response to vitamin B1; IEA:Ensembl; . GO GO:0033197; P:response to vitamin E; IEA:Ensembl; . GO GO:0010043; P:response to zinc ion; IEA:Ensembl; . Gene3D 3.20.20.70; -; 1; . InterPro IPR001731; ALAD; . InterPro IPR030656; ALAD_AS; . InterPro IPR013785; Aldolase_TIM; . PANTHER PTHR11458; PTHR11458; 1; . Pfam PF00490; ALAD; 1; . PIRSF PIRSF001415; Porphbilin_synth; 1; . PRINTS PR00144; DALDHYDRTASE; . SMART SM01004; ALAD; 1; . PROSITE PS00169; D_ALA_DEHYDRATASE; 1; .

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